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psuqshq A: If you are using command-line tools, and are using Ubuntu, then the correct way of installing pdftex is to follow the Debian packaging guidelines. Basically, you'll want to download the pdftex-latex package from Debian's repositories, and then run dpkg -i pdftex-latex. You can read about Debian's package building guidelines, and other basics, here. There is a helpful set of commands by Paul Fulton and Claudio Fragomeni which will convert LaTeX to PDF and other formats. Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes both trachoma, the leading infectious cause of blindness in the world, and the more prevalent sexually transmitted disease, PID. Much is known about the host immune response to C. trachomatis, but much less is known about the specific strategies used by this organism to ensure its survival and propagation. In particular, it is not known what the minimal stimuli are that trigger infection or what the signals are that promote and maintain infection. We recently reported that inhibition of bacterial uptake by host cells stimulates the rapid expulsion of the bacteria from host cells. These observations raise the intriguing possibility that induction of host cell uptake by C. trachomatis may actually be one of the signals promoting cell-to-cell spread and the chronic nature of this disease. The studies proposed herein will build upon this intriguing observation to determine the precise bacterial signals that induce uptake by a non-phagocytic host cell. The work proposed herein will also determine whether the uptake receptor for C. trachomatis is one of the few receptors that allow the bacteria to enter non-phagocytic cells. To facilitate these studies, a series of chimeric bacteria expressing various combinations of C. trachomatis fluorescent reporter proteins will be created. Once we have determined which domains of the surface antigen, CT694, are important for bacterial uptake by non-phagocytic cells, we will focus on the minimal receptor-ligand interactions that drive uptake and how the interactions change during the course of the C. trachomatis infection. These studies will be done in a number of tissue culture models, including the SV40 transformed lymphocyte cell line, BL41, a fibroblast cell line that does not express CT694, and a non-phagocytic cell line that does express CT694.Medication errors in a

 

 

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